Remploy helped 18,500 disabled people find work last year, with strong growth in support for those with severe disabilities or health conditions, the organisation says.
The figure means more than 80,000 disabled and disadvantaged people have been supported over the past five years. Remploy said it expected to pass the 100,000 milestone this year.
Factories employing disabled people have closed in recent years amid protests from unions, but Remploy continues to help with training and recruitment.
Beth Carruthers, Remploy's chief executive, said: "This wonderful achievement of supporting 82,500 people in the last five years is a tribute to the extensive relationships we have with employers and recognition that employing disabled people delivers real social and economic value.
"We are going from strength to strength and this year we anticipate passing the fantastic milestone of supporting into work more than 100,000 disabled and disadvantaged people in the last six years.
"We listen to employers' needs and help them to better understand and enjoy the benefits of employing disabled people, in effect transforming their businesses.
"As a result we achieve the Remploy mission as a social business of helping to transform the lives of tens of thousands of disabled people through sustainable employment."