Snow storms have begun to sweep across the country as Britain prepared for another onslaught of wintry weather.
Accumulations of up to 10cm (3.94 inches) were expected to fall quite widely throughout the day, threatening travel chaos.
The latest cold snap comes less than a fortnight after blizzards brought disruption to schools, airports and traffic networks.
Manchester Airport was forced to suspend runway operations for a period on Tuesday morning to clear snow. It cancelled two flights, while another was diverted to Liverpool, as flurries made their way south.
A band of snow, which hit Scotland, is expected to continue moving down the country and is predicted to reach East Anglia before the end of the day. Meanwhile gale force winds, in excess of 50mph, are likely to batter parts of western Scotland and the West Country.
John Lee, a forecaster with MeteoGroup, the weather division of the Press Association, warned the conditions could cause havoc on the roads.
"There are going to be quite a few wintry showers, which are quite heavy across Scotland and into northern England," he said. "The worst accumulations will be around that area, especially over higher ground. There is the potential for about 5cm-10cm (1.97in-3.94in) but in parts of upland Scotland, where they have already got lying snow, there could be in excess of that."
The snow is expected to hit the South East later in the day but is more likely to fall as rain in London, he said. Strong winds mean blizzards are likely.
The Met Office has issued a Yellow warning - to "be aware" - of severe weather in large parts of the country. The Highways Agency has urged caution on the roads but said motorways and A-roads were running well.
The cold weather is expected to cling on during the next few days with temperatures dipping to minus 4C overnight. Snow showers are expected to ease off in many regions on Wednesday, largely affecting the North Sea coastal areas and the western fringes of England and Wales. They are likely to stay put over Scotland all week.